Moving forward will not be for the faint of heart. But if the next cen — James D. Watson

"To make a huge success, a scientist must be prepared to get into deep trouble. Sometime or another, someone will tell you that you are not ready to do something. … If you are going to make a big jump in science, you will very likely be unqualified to succeed by definition. The truth, however, wont save you from criticism. Your very willingness to take on a very big goal will offend some people who will think that you are too big for your britches and crazy to boot."

"The brain is the last and grandest biological frontier, the most complex thing we have yet discovered in our universe. It contains hundreds of billions of cells interlinked through trillions of connections. The brain boggles the mind."

"I turned against the left wing because they dont like genetics, because genetics implies that sometimes in life we fail because we have bad genes. They want all failure in life to be due to the evil system."

"To have success in science, you need some luck. But to succeed in science, you need a lot more than luck. And its not enough to be smart — lots of people are very bright and get nowhere in life. In my view, you have to combine intelligence with a willingness not to follow conventions when they block your path forward."

"Should you be allowed to make an anti-Semitic remark? Yes, because some anti-Semitism is justified. Just like some anti-Irish feeling is justified. If you cant be criticized, thats very dangerous. The whole Larry Summers thing, to say that men are a bit strange and their strangest quality is their ability to understand mathematics -- youre not supposed to even think it."

"There is only one science, physics: everything else is social work."

"The true Vedantic spirit does not start out with a system of preconceived ideas. It possesses absolute liberty and unrivalled courage among religions with regard to the facts to be observed and the diverse hypotheses it has laid down for their coordination. Never having been hampered by a priestly order, each man has been entirely free to search wherever he pleased for the spiritual explanation of the spectacle of the universe."

"The decades-long draconian approach of the international community to preventing drug dependence is now widely recognised to have been a human disaster, both in the failure to tackle the primary issue and for the additional human suffering caused, including the patients in moderate to severe pain who have been prevented from accessing essential medicines. We need politicians and policymakers to be courageous enough to admit that past policies were misguided, and to rebalance their priorities and approaches in ways that will reduce human suffering."

"O may I join the choir invisible Of those immortal dead who live again In minds made better by their presence; live In pulses stirred to generosity, In deeds of daring rectitude, in scorn For miserable aims that end with self, In thoughts sublime that pierce the night like stars, And with their mild persistence urge mens search To vaster issues."

"There is no question that religions have historically played the role of making people contented with their lot. ...such a doctrine would be very appealing to the ruling classes of a society. ...Many societies, for this reason alone, encourage the contentment with your lot that the religious premise of heaven affords."

"Value of a man depends upon his courage; his veracity depends upon his self-respect and his chastity depends upon his sense of honor."

"What counts most is holding on. The growth of a train of thought is not a direct forward flow. There is a succession of spurts separated by intervals of stagnation, frustration, and discouragement. If you hold on, there is bound to come a certain clarification. The unessential components drop off and a coherent, lucid whole begins to take shape."